A Sustainable Improvement of ?-Bromoalkylphosphonates Synthesis to Access Novel KuQuinones

Owing to the attractiveness of organic phosphonic acids and esters in pharmacological field functionalization conductive metal-oxides, research effective synthetic protocols is pivotal. Among others, ?-bromoalkylphosphonates are gaining particular attention because they useful building blocks for tailored complex molecules. Hence, this work, optimization Michaelis–Arbuzov reaction conditions has been performed, improve process sustainability while maintaining good yields. Synthesized have successfully adopted synthesis new KuQuinone phosphonate and, by hydrolysis, acid derivatives obtained first time. Considering high affinity with KuQuinones bearing terminal groups promising candidates biomedical photo(electro)chemical applications.